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미국탈모협회의 말을 인용하면 미국 남성의 88%가 50대까지 머리카락이 가늘어지고 수가 적어지는 것을 경험했다. 탈모가 심해지는 원인은 모낭줄기세포의 수가 줄어들어서다. 모낭줄기세포는 세포 분열을 통해 모낭에서 새로운 모발이 나오도록 돕는다. 줄기세포 수가 적어지는 것은 자연스러운 노화의 공정이지만 이런 반응이 심해지는 이유는 명확히 밝혀지지 않았다.
머리카락이식 시 이식하는 부위의 밀도뿐만 아니라 채취하는 부위의 밀도에도 신경 써야 한다. 또한 채취한 모낭의 생착률을 높이기 위해 모낭의 상태에 주순해 채취도구인 펀치의 각도, 두께, 방향 등에 친절한 주의를 기울일 필요가 있다. 0.8밀리미터의 펀치는 내경이 좁아 단일모 채취에 적합다만 모낭의 파열이 생성할 가능성이 있고 1.3밀리미터의 펀치는 내경이 넓어 쉽게 모낭을